Enantiomeric Separation of Linezolid by Chiral Reversed-Phase Liquid Chromatography
نویسندگان
چکیده
منابع مشابه
Enantiomeric separation of Linezolid by chiral reversed-phase liquid chromatography.
A chiral liquid chromatographic method is developed for the enantiomeric resolution of Linezolid, (S)(-)-N-[[-3-(3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl] methyl] acetamide, an antibiotic in bulk drugs. The enantiomers of Linezolid are resolved on a Chiralcel OJ-RH column using a mobile phase system containing 150mM di-sodium hydrogen phosphate buffer (pH 4.5)-acetonitrile (86:14,...
متن کاملSeparation of Somatropin and Its Degradation Products by High-Performance Liquid Chromatography Using a Reversed-Phase Polymeric Column
The accurate prediction of protein stability is one of the most challenging goals in protein formulation and delivery. In this study, a gradient RP-HPLC method is described for the separation of human growth hormone (hGH) variants as deamidated and oxidized forms. The methodology employed a polymeric poly (styrene-co-divinylbenzene) column and a 1mL/min flow rate of a linear gradient of 0.1% v/...
متن کاملSeparation of Somatropin and Its Degradation Products by High-Performance Liquid Chromatography Using a Reversed-Phase Polymeric Column
The accurate prediction of protein stability is one of the most challenging goals in protein formulation and delivery. In this study, a gradient RP-HPLC method is described for the separation of human growth hormone (hGH) variants as deamidated and oxidized forms. The methodology employed a polymeric poly (styrene-co-divinylbenzene) column and a 1mL/min flow rate of a linear gradient of 0.1% v/...
متن کاملEnantiomeric Separation and Circular Dichroism Detection of Metalaxyl Acid Metabolite by Chiral High Performance Liquid Chromatography
The enantiomers of metalaxyl acid metabolite (MX-acid) were separated by HPLC using cellulose-tris-(3,5-dimethylphenyl-carbamate) (CDMPC) as chiral stationary phase. The effects of mobile phase composition, flow rate and column temperature on the resolution were investigated and good separation was achieved with n-hexane/2-propanol/trifluoroacetic acid as mobile phase. The circular dichroisms d...
متن کاملEnantiomeric Separation of Rivaroxaban by a Chiral Liquid Chromatographic Method
Methods: An enantioselective reversed phase high performance liquid chromatographic method was developed and validated. The enantiomers of rivaroxaban was resolved on a Chiralcel OD-H (250 mm × 4.6 mm, 5 mm) column using a mobile phase system containing n-hexane –isopropanol (50: 50 v/v/) and column temperature at 35°C. The resolution between the enantiomers was not less than 2.0. The developed...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Chromatographic Science
سال: 2008
ISSN: 0021-9665,1945-239X
DOI: 10.1093/chromsci/46.9.764